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A recent study showed that between 2009 and 2015, the prevalence of tobacco smoking in the Saudi population substantially increased from 8.9% to 19.5% 6

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This review examines the intricate relationship between cigarette smoking, smoking cessation therapies and anti-TB drugs, focusing on the impact of tobacco smoking compounds on liver detoxifying systems, such as influence of polycyclic aromatic hydrocarbons (PAHs) on hepatic cytochrome P450 (CYP450) enzymes mostly, and on metabolism of antituberculous medications